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What is Xiapex?

Xiapex is an injection consisting of enzymes that are used to break down stiffened tissue. It is used to treat conditions such as Dupuytren’s contracture and Peyronie’s disease. 

What is Dupuytren’s Contracture?

Dupuytren’s contracture is a condition that affects the palm and fingers. It is characterized by inward bending of one or more fingers due to stiffening of the connective tissue in the palm of the hand which may later form a rope-like cord.

How Does Xiapex Work in Treating Dupuytren’s Contracture?

Xiapex works by breaking down the stiffened rope-like cord allowing the affected finger to extend more normally.

What Does Xiapex Treatment Involve?

Your physician will inject Xiapex directly into the affected area using a fine needle. After the injection, the hand is wrapped in a gauze dressing, and you will be checked for signs of any allergic reaction or discomfort before returning home. 

What are the Instructions to be Followed Post Xiapex Treatment?

Your nurse or physician will provide you with instructions to follow after Xiapex treatment, such as:

  • Not to perform any strenuous activities with the affected hand
  • Avoiding straightening or bending the fingers of the affected hand
  • Keeping the hand elevated above elbow level
  • Avoiding getting the dressing wet

Follow-up Visit

On your next visit, your doctor will perform a finger extension procedure where the affected finger is straightened out for around 10 to 20 seconds, stretching out the weakened cord. It is normal to experience some bruising and swelling following the finger extension procedure. You will receive a finger splint to be worn at night. Pain medications are prescribed if necessary. You will also be instructed on specific hand exercises to perform at home.

Your doctor will check your progress in a month’s time. A repeat procedure may sometimes be recommended. A separate treatment is required if more than one cord is present.

What are the Side Effects of Xiapex Treatment?

Possible side effects that are associated with Xiapex treatment include:

  • Tenderness
  • Swelling
  • Pain
  • Bleeding
  • Bruising
  • Itching
  • Redness and/or rash

Related Topics:

Dallas County Medical Society American Academy of Orthopaedic Surgeons Texas Medical Association American Society for Surgery of the Hand